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Gene name:
ANGPT1;
Protein name:
Angiopoietin-1(ANG-1);
Alternative:
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
N/A
Function:
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
Subcellular Location:
Secreted
Protein Attributes:
Sequence length:
497
Sequence:
50:
MTVFLSFAFL | AAILTHIGCS | NQRRSPENGG | RRYNRIQHGQ | CAYTFILPEH |
100:
DGNCRESTTD | QYNTNALQRD | APHVGPDFSS | QKLQHLEHVM | ENYTQWLQKI |
150:
ENYIVENMKS | EMAQIQQNAV | QNHTATMLEI | GTSLLSQTAE | QTRKLTDVET |
200:
QVLNQTSRLE | IQLLENSLST | YKLEKQLLQQ | TNEILKIHEK | NSLLEHKILE |
250:
MEGKHKEEWD | TLKEERENLQ | VLVTRQTYII | QELEKQLNRA | TNNNSVLQKQ |
300:
QLELMDTVHN | LVNLCTKEVL | LKGGKKEEEK | PFRDCADVYQ | AGFNKSGIYT |
350:
IYINNMPEPK | KVFCNMDVNG | GGWTVIQHRE | DGSLDFQRGW | KEYKMGFGNP |
400:
SGEYWLGNEF | IFAITSQRQY | TLRIELMDCE | GNRAYSQYDR | FHIGNEKQNY |
450:
RLYLKCHTGT | AGKQSSLILH | GADFSTKDAD