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Gene name:
ANG;
Protein name:
Angiogenin;
Alternative:
Ribonuclease 5(RNase 5);
Organism:
Rabbit (Oryctolagus cuniculus).
General Annotation
Sub Unit:
Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.
Function:
May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Subcellular Location:
Secreted
Protein Attributes:
Sequence length:
125
Sequence:
50:
QDDSRYKHFL | TQHYDAKPFG | RNDRYCETMM | KRRDLTSPCK | DTNTFVHGNK |
100:
GSIKDVCEDK | NGKPYGKNFR | ISKSSFQVTT | CKHVGGSPWP | PCRYRATSGS |
125:
RNIVIACENG | LPVHFDESVF | QQKVH
3D Structure:
N/A
Predicted Eptitope:
N/A
Related Databases
SMR:
P31347
Pfam:
PF00074
Uniprot:
P31347